{"id":17914,"date":"2024-10-18T17:00:53","date_gmt":"2024-10-18T15:00:53","guid":{"rendered":"https:\/\/biomex-stage.ultrabold.de\/?page_id=17914"},"modified":"2024-10-21T13:19:33","modified_gmt":"2024-10-21T11:19:33","slug":"%e6%8f%ad%e5%bc%80%e7%99%8c%e7%97%87%e7%9a%84%e5%a4%8d%e6%9d%82%e9%9d%a2%e7%ba%b1-%e4%bb%8e%e5%8f%98%e5%bc%82%e7%bb%86%e8%83%9e%e5%88%b0%e5%8a%a8%e6%80%81%e7%96%be%e7%97%85","status":"publish","type":"page","link":"https:\/\/biomex.de\/zh-hans\/%e6%8f%ad%e5%bc%80%e7%99%8c%e7%97%87%e7%9a%84%e5%a4%8d%e6%9d%82%e9%9d%a2%e7%ba%b1-%e4%bb%8e%e5%8f%98%e5%bc%82%e7%bb%86%e8%83%9e%e5%88%b0%e5%8a%a8%e6%80%81%e7%96%be%e7%97%85\/","title":{"rendered":"\u63ed\u5f00\u764c\u75c7\u7684\u590d\u6742\u9762\u7eb1\uff1a\u4ece\u53d8\u5f02\u7ec6\u80de\u5230\u52a8\u6001\u75be\u75c5"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"17914\" class=\"elementor elementor-17914 elementor-17860\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7c703bd elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"7c703bd\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-65b1b2b\" data-id=\"65b1b2b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f51b1bd elementor-widget elementor-widget-template\" data-id=\"f51b1bd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"template.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-template\">\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-731bb81 elementor-section-full_width elementor-section-stretched elementor-section-height-default elementor-section-height-default\" data-id=\"731bb81\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b914d68\" data-id=\"b914d68\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-734bf37 breadcrumb elementor-widget elementor-widget-shortcode\" data-id=\"734bf37\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\t\t<div data-elementor-type=\"section\" data-elementor-id=\"16139\" class=\"elementor elementor-16139 elementor-1114 elementor-1114\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-60cebac9 elementor-section-full_width elementor-section-height-min-height elementor-section-height-default elementor-section-items-middle\" data-id=\"60cebac9\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-36426147\" data-id=\"36426147\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-16722c7e elementor-align-left elementor-widget elementor-widget-breadcrumbs\" data-id=\"16722c7e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"breadcrumbs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"breadcrumbs\"><span><span><a href=\"https:\/\/biomex.de\/zh-hans\/\">Home<\/a><\/span><\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-50ea35f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"50ea35f\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-bd4efe6\" data-id=\"bd4efe6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e84de60 elementor-widget elementor-widget-spacer\" data-id=\"e84de60\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-746c2bf elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"746c2bf\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d3de4b8\" data-id=\"d3de4b8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4015ffc elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"4015ffc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">\u63ed\u5f00\u764c\u75c7\u7684\u590d\u6742\u9762\u7eb1\uff1a\u4ece\u53d8\u5f02\u7ec6\u80de\u5230\u52a8\u6001\u75be\u75c5<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3e1c055 elementor-widget elementor-widget-spacer\" data-id=\"3e1c055\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-4a89966 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4a89966\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-7394aa0\" data-id=\"7394aa0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0497987 elementor-widget elementor-widget-text-editor\" data-id=\"0497987\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"letter-spacing: 0.3px; text-align: start;\">\u751f\u547d\u79d1\u5b66\u9ad8\u7ea7\u79d1\u5b66\u5bb6Djeda Belharazem\u535a\u58eb <span style=\"color: #0000ff;\"><a style=\"color: #0000ff; font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-size: var( --e-global-typography-text-font-size ); font-weight: var( --e-global-typography-text-font-weight ); line-height: var( --e-global-typography-text-line-height ); letter-spacing: var( --e-global-typography-text-letter-spacing );\" href=\"mailto:djeda.belharazem@biomex.de\" target=\"_blank\" rel=\"noopener\">djeda.belharazem@biomex.de<\/a><\/span><\/p><p style=\"letter-spacing: 0.3px; text-align: start;\">\u9500\u552e\u548c\u9879\u76ee\u526f\u603b\u88c1Manish Kumar\u535a\u58eb <span style=\"color: #0000ff;\"><a style=\"color: #0000ff; font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-size: var( --e-global-typography-text-font-size ); font-weight: var( --e-global-typography-text-font-weight ); line-height: var( --e-global-typography-text-line-height ); letter-spacing: var( --e-global-typography-text-letter-spacing );\" href=\"mailto:manish.kumar@biomex.de\" target=\"_blank\" rel=\"noopener\">manish.kumar@biomex.de<\/a><\/span><\/p><p><strong>\u5f15\u8a00<\/strong><br \/>\u764c\u75c7\u7814\u7a76\u4f20\u7edf\u4e0a\u4e00\u76f4\u5c06\u91cd\u70b9\u653e\u5728\u57fa\u56e0\u7a81\u53d8\u4e0a\uff0c\u5c06\u5176\u89c6\u4e3a\u80bf\u7624\u53d1\u5c55\u548c\u8fdb\u5c55\u7684\u4e3b\u8981\u9a71\u52a8\u56e0\u7d20\u3002\u7136\u800c\uff0c\u6700\u8fd1\u7684\u8fdb\u5c55\u8868\u660e\uff0c\u764c\u75c7\u8fdc\u6bd4\u5355\u7eaf\u7684\u57fa\u56e0\u53d8\u5f02\u590d\u6742\u5f97\u591a\u3002\u5b83\u662f\u4e00\u79cd\u591a\u65b9\u9762\u7684\u3001\u4e0d\u65ad\u53d1\u5c55\u7684\u75be\u75c5\uff0c\u5728\u5176\u5468\u56f4\u73af\u5883\u7684\u590d\u6742\u751f\u6001\u7cfb\u7edf\u4e2d\u84ec\u52c3\u53d1\u5c55\uff0c\u8fd9\u79cd\u73af\u5883\u88ab\u79f0\u4e3a\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u3002\u4e3a\u4e86\u6709\u6548\u5bf9\u6297\u764c\u75c7\uff0c\u7814\u7a76\u4eba\u5458\u5fc5\u987b\u5c06\u91cd\u70b9\u4ece\u7a81\u53d8\u7ec6\u80de\u8f6c\u79fb\u5230\u4e86\u89e3\u764c\u7ec6\u80de\u4e0e\u5176\u73af\u5883\u4e4b\u95f4\u7684\u52a8\u6001\u76f8\u4e92\u4f5c\u7528\u4e0a\u3002\u8fd9\u79cd\u7efc\u5408\u65b9\u6cd5\u4e3a\u5f00\u53d1\u65e8\u5728\u963b\u6b62\u80bf\u7624\u53d1\u5c55\u548c\u8f6c\u79fb\u7684\u521b\u65b0\u7597\u6cd5\u63d0\u4f9b\u4e86\u65b0\u7684\u673a\u4f1a\u3002<\/p><p><strong>\u80bf\u7624\u5fae\u73af\u5883\uff08TME<\/strong><strong>\uff09\uff1a\u764c\u75c7\u7814\u7a76\u7684\u65b0\u9886\u57df<\/strong><br \/>\u5728\u5bf9\u6297\u764c\u75c7\u7684\u8fc7\u7a0b\u4e2d\uff0c\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u65e2\u5e26\u6765\u4e86\u6311\u6218\uff0c\u4e5f\u5e26\u6765\u4e86\u673a\u9047\u3002TME\u7531\u764c\u7ec6\u80de\u3001\u514d\u75ab\u7ec6\u80de\u3001\u6210\u7ea4\u7ef4\u7ec6\u80de\u548c\u7ec6\u80de\u5916\u57fa\u8d28\uff08ECM\uff09\u6210\u5206\u7684\u5f02\u8d28\u6df7\u5408\u7269\u7ec4\u6210\uff0c\u662f\u4e00\u4e2a\u52a8\u6001\u7cfb\u7edf\uff0c\u5728\u8c03\u8282\u80bf\u7624\u751f\u957f\u3001\u8f6c\u79fb\u548c\u8010\u836f\u6027\u65b9\u9762\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\uff08Hanahan &amp; Weinberg\uff0c2011\uff09\u3002\u4f20\u7edf\u7684\u764c\u75c7\u7597\u6cd5\u4e3b\u8981\u9488\u5bf9\u764c\u7ec6\u80de\uff0c\u4f46\u7531\u4e8e\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u6297\u836f\u673a\u5236\uff0c\u5f80\u5f80\u65e0\u6cd5\u594f\u6548\u3002\u8fd9\u51f8\u663e\u4e86\u5f00\u53d1\u4f53\u5916\u4e34\u5e8a\u524d\u6a21\u578b\u7684\u91cd\u8981\u6027\uff0c\u8fd9\u4e9b\u6a21\u578b\u53ef\u6a21\u62df\u80bf\u7624\u5fae\u73af\u5883\uff0c\u4ece\u800c\u66f4\u597d\u5730\u9884\u6d4b\u6cbb\u7597\u6548\u679c\u5e76\u5f00\u53d1\u66f4\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\uff08Whiteside\uff0c2008\uff09\u3002\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u5173\u952e\u53c2\u4e0e\u8005\u5305\u62ec\u80bf\u7624\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08CAFs\uff09\u548c\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff08TAMs\uff09\uff0c\u80bf\u7624\u4f1a\u62db\u52df\u8fd9\u4e9b\u7ec6\u80de\u6765\u652f\u6301\u5176\u751f\u957f\u548c\u5b58\u6d3b\u3002CAFs\u901a\u8fc7\u5206\u6ccc\u751f\u957f\u56e0\u5b50\u3001\u91cd\u5851ECM\u548c\u521b\u9020\u4fc3\u80bf\u7624\u73af\u5883\u6765\u4fc3\u8fdb\u80bf\u7624\u8fdb\u5c55\uff08Kalluri\uff0c2016\uff09\u3002TAMs\u6839\u636e\u5176\u6781\u5316\u72b6\u6001\uff0c\u53ef\u4ee5\u4fc3\u8fdb\u6216\u6291\u5236\u80bf\u7624\u751f\u957f\uff08Noy &amp; Pollard\uff0c2014\uff09\u3002\u4e86\u89e3\u9a71\u52a8\u8fd9\u4e9b\u76f8\u4e92\u4f5c\u7528\u7684\u673a\u5236\u53ca\u5176\u5728\u764c\u75c7\u8fdb\u5c55\u4e2d\u7684\u4f5c\u7528\u5bf9\u4e8e\u5f00\u53d1\u7834\u574fTME\u652f\u6301\u4f5c\u7528\u7684\u7597\u6cd5\u81f3\u5173\u91cd\u8981\u3002<\/p><p><strong>\u8feb\u5207\u9700\u8981\u4eba\u7c7b\u6765\u6e90\u7684ECM<\/strong><br \/>\u764c\u75c7\u7814\u7a76\u9762\u4e34\u7684\u4e3b\u8981\u6311\u6218\u4e4b\u4e00\u662f\u7f3a\u4e4f\u53ef\u9760\u4e14\u4e0e\u751f\u7269\u5b66\u76f8\u5173\u7684\u6a21\u578b\u6765\u7814\u7a76TME\u3002\u4f20\u7edf\u7684\u5408\u6210ECM\u662f\u9759\u6001\u7684\uff0c\u65e0\u6cd5\u6355\u6349\u4f53\u5185\u4eba\u7c7b\u80bf\u7624\u73af\u5883\u7684\u590d\u6742\u6027\uff08Cox\u548cErler\uff0c2011\uff09\u3002\u4e3a\u4e86\u5145\u5206\u4e86\u89e3\u764c\u75c7\u7684\u6297\u836f\u6027\u548c\u6269\u6563\u673a\u5236\uff0c\u7814\u7a76\u4eba\u5458\u9700\u8981\u4e00\u79cd\u4e0d\u542b\u52a8\u7269\u6210\u5206\u3001\u6e90\u81ea\u4eba\u4f53\u7684ECM\uff0c\u4ee5\u53cd\u6620\u80bf\u7624\u7ec6\u80de\u3001CAFs\u3001TAMs\u548c\u5176\u4ed6TME\u6210\u5206\u4e4b\u95f4\u7684\u52a8\u6001\u76f8\u4e92\u4f5c\u7528\u3002100%\u6e90\u81ea\u4eba\u4f53\u7684ECM\u4e3a\u4eba\u7c7b\u7ec6\u80de\u7814\u7a76\u63d0\u4f9b\u4e86\u66f4\u5177\u4ea4\u4e92\u6027\u548c\u51c6\u786e\u6027\u7684\u73af\u5883\uff0c\u4ece\u800c\u63d0\u4f9b\u4e86\u4e00\u79cd\u521b\u65b0\u7684\u89e3\u51b3\u65b9\u6848\u3002\u8fd9\u6709\u52a9\u4e8e\u66f4\u6df1\u5165\u5730\u4e86\u89e3TME\u5982\u4f55\u5f71\u54cd\u764c\u75c7\u7684\u8fdb\u5c55\u3001\u8f6c\u79fb\u548c\u6cbb\u7597\u8010\u836f\u6027\u3002<\/p><p><strong>\u4e0a\u76ae-<\/strong><strong>\u95f4\u8d28\u8f6c\u5316\uff08EMT<\/strong><strong>\uff09\u548c\u8f6c\u79fb<\/strong><br \/>\u8f6c\u79fb\u662f\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u5360\u6b64\u7c7b\u6b7b\u4ea1\u768490%\u4ee5\u4e0a\uff08Chaffer &amp; Weinberg\uff0c2011\uff09\u3002\u8f6c\u79fb\u8fc7\u7a0b\u6d89\u53ca\u4e00\u7cfb\u5217\u590d\u6742\u7684\u6b65\u9aa4\uff0c\u9996\u5148\u662f\u4e0a\u76ae-\u95f4\u8d28\u8f6c\u5316\uff08EMT\uff09\u3002\u5728EMT\u8fc7\u7a0b\u4e2d\uff0c\u80bf\u7624\u7ec6\u80de\u5931\u53bb\u4e0a\u76ae\u7ec6\u80de\u7279\u5f81\uff0c\u83b7\u5f97\u95f4\u5145\u8d28\u7ec6\u80de\u7279\u5f81\uff0c\u4ece\u800c\u80fd\u591f\u4ece\u539f\u53d1\u80bf\u7624\u90e8\u4f4d\u8f6c\u79fb\uff08Nieto\u7b49\u4eba\uff0c2016\uff09\u3002TME\u901a\u8fc7\u63d0\u4f9b\u9a71\u52a8EMT\u548c\u652f\u6301\u80bf\u7624\u7ec6\u80de\u4fb5\u5165\u5468\u56f4\u7ec4\u7ec7\u7684\u4fe1\u53f7\uff0c\u5728\u8fd9\u4e00\u8fc7\u7a0b\u4e2d\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\u3002\u4e00\u65e6\u80bf\u7624\u7ec6\u80de\u8131\u79bb\u539f\u53d1\u90e8\u4f4d\uff0c\u5b83\u4eec\u5c31\u4f1a\u8fdb\u5165\u8840\u6db2\uff0c\u6700\u7ec8\u5728\u8fdc\u7aef\u5668\u5b98\u5b9a\u690d\uff0c\u5f62\u6210\u7ee7\u53d1\u6027\u80bf\u7624\u3002<br \/>\u4e86\u89e3TME\u5728\u8f6c\u79fb\u4e2d\u7684\u4f5c\u7528\u5bf9\u4e8e\u5f00\u53d1\u80fd\u591f\u9884\u9632\u764c\u75c7\u6269\u6563\u7684\u6cbb\u7597\u65b9\u6cd5\u81f3\u5173\u91cd\u8981\u3002\u4eba\u7c7b\u6765\u6e90\u7684ECM\u6a21\u578b\uff08\u5982homoGel\u00ae\uff09\u4e3a\u7814\u7a76\u9a71\u52a8EMT\u548c\u8f6c\u79fb\u7684\u4fe1\u53f7\u548c\u76f8\u4e92\u4f5c\u7528\u63d0\u4f9b\u4e86\u7406\u60f3\u7684\u5e73\u53f0\uff0c\u4e3a\u764c\u75c7\u7ec6\u80de\u5982\u4f55\u5728\u8fdc\u5904\u5668\u5b98\u4e2d\u5efa\u7acb\u65b0\u80bf\u7624\u63d0\u4f9b\u4e86\u65b0\u7684\u89c1\u89e3\u3002<\/p><p><strong>ECM<\/strong><strong>\u548c\u8840\u7ba1\u751f\u6210<\/strong><br \/>\u8840\u7ba1\u7684\u5f62\u6210\u6216\u8840\u7ba1\u751f\u6210\u5bf9\u4e8e\u80bf\u7624\u751f\u957f\u548c\u7ec4\u7ec7\u518d\u751f\u81f3\u5173\u91cd\u8981\u3002\u5728\u764c\u75c7\u4e2d\uff0c\u80bf\u7624\u7ec6\u80de\u4f9d\u9760\u65b0\u7684\u8840\u7ba1\u6765\u63d0\u4f9b\u8425\u517b\u548c\u6c27\u6c14\uff0c\u4f7f\u5176\u80fd\u591f\u751f\u957f\u548c\u8f6c\u79fb\uff08Hanahan\u548cFolkman\uff0c1996\uff09\u3002\u5728\u518d\u751f\u533b\u5b66\u4e2d\uff0c\u8840\u7ba1\u751f\u6210\u5bf9\u4e8e\u786e\u4fdd\u65b0\u5de5\u7a0b\u7ec4\u7ec7\u7684\u5b58\u6d3b\u548c\u6574\u5408\u540c\u6837\u91cd\u8981\u3002\u4eba\u7c7b\u6765\u6e90\u7684ECM\uff08\u5982homoGel\u00ae\uff09\u4e3a\u7814\u7a76ECM\u5728\u8840\u7ba1\u751f\u6210\u4e2d\u7684\u4f5c\u7528\u4ee5\u53ca\u5f00\u53d1\u4fc3\u8fdb\u6216\u6291\u5236\u8840\u7ba1\u5f62\u6210\u7684\u7597\u6cd5\u63d0\u4f9b\u4e86\u5173\u952e\u5e73\u53f0\uff0c\u5177\u4f53\u53d6\u51b3\u4e8e\u6240\u9700\u7684\u7ed3\u679c\u3002<\/p><p><strong>Extracellular Matrix (ECM) and Stem Cells in Regenerative Medicine<\/strong><br \/>The ECM is fundamental to regenerative medicine, serving as a dynamic scaffold that regulates cell behavior, tissue growth, and organ regeneration. In tissue engineering and regenerative therapies, the ECM\u2018s structural and biochemical cues guide the differentiation, proliferation, and function of cells, especially stem cells. Advances in human-derived ECM, such as homoGel\u00ae, offer new opportunities for creating biologically relevant models that are crucial for advancing therapeutic development.<\/p><p><strong>ECM<\/strong><strong>\u5728\u5e72\u7ec6\u80de\u6cbb\u7597\u4e2d\u7684\u89d2\u8272<\/strong><br \/>\u5e72\u7ec6\u80de\uff0c\u7279\u522b\u662f\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u548c\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSCs\uff09\uff0c\u5728\u518d\u751f\u533b\u5b66\u9886\u57df\u5177\u6709\u5de8\u5927\u6f5c\u529b\uff0c\u56e0\u4e3a\u5b83\u4eec\u80fd\u591f\u5206\u5316\u6210\u5404\u79cd\u7ec6\u80de\u7c7b\u578b\u3002\u7136\u800c\uff0c\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u6548\u679c\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u53d6\u51b3\u4e8e\u5468\u56f4\u7684ECM\uff0c\u5b83\u63d0\u4f9b\u5173\u952e\u7684\u751f\u5316\u4fe1\u53f7\u548c\u673a\u68b0\u652f\u6301\uff0c\u4ee5\u7ef4\u6301\u8fd9\u4e9b\u7ec6\u80de\u7684\u5e72\u7ec6\u80de\u7279\u6027\uff08Chen\u7b49\u4eba\uff0c2021\uff09\u3002\u4f20\u7edf\u7684\u5408\u6210ECM\uff0c\u4f8b\u5982\u57fa\u4e8e\u805a\u4e59\u4e8c\u9187\uff08PEG\uff09\u7684\u6c34\u51dd\u80f6\uff0c\u7f3a\u4e4f\u590d\u5236\u4eba\u4f53\u4f53\u5185\u73af\u5883\u6240\u9700\u7684\u751f\u7269\u590d\u6742\u6027\u3002\u8fd9\u4e9b\u5408\u6210\u6750\u6599\u901a\u5e38\u65e0\u6cd5\u652f\u6301\u7ec6\u80de\u5206\u5316\u548c\u7ec4\u7ec7\u518d\u751f\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u6e90\u81ea\u4eba\u4f53\u7684ECM\uff0c\u4f8b\u5982homoGel\u00ae\uff0c\u542b\u6709\u4e0e\u4eba\u4f53\u7ec4\u7ec7\u9ad8\u5ea6\u76f8\u4f3c\u7684\u5929\u7136\u751f\u5316\u4fe1\u53f7\uff0c\u53ef\u786e\u4fddMSC\u548ciPSC\u4fdd\u6301\u81ea\u6211\u66f4\u65b0\u548c\u5206\u5316\u6210\u529f\u80fd\u6027\u7ec4\u7ec7\u7684\u80fd\u529b\uff08Yin\u7b49\u4eba\uff0c2021\uff09\u3002<br \/>\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0c\u4eba\u6e90\u6027ECM\u53ef\u4ee5\u901a\u8fc7\u4fc3\u8fdb\u7279\u5b9a\u8c31\u7cfb\u627f\u8bfa\uff08\u5982\u6210\u9aa8\u6216\u8f6f\u9aa8\u5f62\u6210\uff09\u6765\u5f71\u54cd\u5e72\u7ec6\u80de\u7684\u547d\u8fd0\uff0c\u5728\u7ec4\u7ec7\u7279\u5f02\u6027\u73af\u5883\u4e2d\u3002\u8fd9\u8868\u660e\uff0c\u4eba\u6e90\u6027ECM\uff08\u5982homoGel\u00ae\uff09\u53ef\u4ee5\u4f5c\u4e3a\u66f4\u6709\u6548\u7684\u5e73\u53f0\uff0c\u7528\u4e8e\u521b\u5efa\u7ec4\u7ec7\u7279\u5f02\u6027\u518d\u751f\u7597\u6cd5\uff08Lau et al.\uff0c2021\uff09\u3002<\/p><p><strong>ECM<\/strong><strong>\u5728\u7ec4\u7ec7\u5de5\u7a0b\u548c\u5668\u5b98\u91cd\u5efa<\/strong>\u4e2d\u7684\u5e94\u7528<br \/>\u7ec4\u7ec7\u5de5\u7a0b\u9700\u8981\u4e00\u79cd\u80fd\u591f\u63d0\u4f9b\u7ed3\u6784\u5b8c\u6574\u6027\u5e76\u4fc3\u8fdb\u529f\u80fd\u6027\u7ec4\u7ec7\u5f62\u6210\u7684ECM\u3002\u6765\u81ea\u4eba\u4f53\u7684ECM\uff08\u5982homoGel\u00ae\uff09\u80fd\u591f\u63d0\u4f9b\u652f\u6301\u76ae\u80a4\u3001\u8f6f\u9aa8\u548c\u9aa8\u9abc\u7b49\u590d\u6742\u7ec4\u7ec7\u5f62\u6210\u6240\u9700\u7684\u57fa\u672c\u751f\u957f\u56e0\u5b50\u3001\u7ed3\u6784\u86cb\u767d\u548c\u673a\u68b0\u7279\u6027\uff0c\u4e3a\u7ec4\u7ec7\u5de5\u7a0b\u63d0\u4f9b\u4e86\u5353\u8d8a\u7684\u5e73\u53f0\uff08Gao\u7b49\u4eba\uff0c2021\uff09\u3002<br \/>\u5728\u5668\u5b98\u91cd\u5efa\u4e2d\uff0c\u8840\u7ba1\u751f\u6210\u662f\u4e00\u4e2a\u5173\u952e\u6311\u6218\u3002\u5982\u679c\u6ca1\u6709\u5f3a\u5927\u7684\u8840\u6db2\u4f9b\u5e94\uff0c\u5de5\u7a0b\u7ec4\u7ec7\u5c31\u65e0\u6cd5\u5b58\u6d3b\u6216\u4e0e\u5bbf\u4e3b\u7ec4\u7ec7\u6574\u5408\u3002\u4eba\u4f53\u6765\u6e90\u7684ECM\u5df2\u88ab\u8bc1\u660e\u53ef\u901a\u8fc7\u63d0\u4f9b\u5f62\u6210\u65b0\u8840\u7ba1\u6240\u9700\u7684\u751f\u5316\u4fe1\u53f7\u6765\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\uff08Jang\u7b49\u4eba\uff0c2022\uff09\u3002homoGel\u00ae\u7684\u4eba\u6e90\u6027\u6210\u5206\u4f7f\u5176\u80fd\u591f\u6709\u6548\u652f\u6301\u65b0\u8840\u7ba1\u7cfb\u7edf\u7684\u751f\u957f\uff0c\u8fd9\u5bf9\u4e8e\u53d1\u80b2\u529f\u80fd\u6027\u7ec4\u7ec7\u548c\u5668\u5b98\u81f3\u5173\u91cd\u8981\u3002<br \/>\u6700\u65b0\u7814\u7a76\u8868\u660e\uff0c\u4f7f\u7528\u4eba\u4f53\u6765\u6e90\u7684ECM\u652f\u67b6\u53ef\u6539\u5584\u809d\u810f\u548c\u80be\u810f\u7b49\u5668\u5b98\u7684\u91cd\u5efa\u6548\u679c\uff0c\u56e0\u4e3a\u8840\u7ba1\u751f\u6210\u5bf9\u4e8e\u8fd9\u4e9b\u5668\u5b98\u7684\u957f\u671f\u529f\u80fd\u81f3\u5173\u91cd\u8981\u3002\u901a\u8fc7\u4fc3\u8fdb\u7c7b\u4f3c\u5929\u7136\u7684\u73af\u5883\uff0chomoGel\u00ae\u6709\u671b\u663e\u8457\u63d0\u9ad8\u5668\u5b98\u5de5\u7a0b\u548c\u79fb\u690d\u7684\u6210\u529f\u7387\uff08Zhao\u7b49\u4eba\uff0c2021\uff09\u3002<\/p><p><strong>\u6458\u8981<\/strong><br \/>100%\u6e90\u81ea\u4eba\u4f53\u7684ECM\u7684\u5f00\u53d1\u6807\u5fd7\u7740\u764c\u75c7\u7814\u7a76\u548c\u518d\u751f\u533b\u5b66\u7684\u91cd\u5927\u8fdb\u6b65\u3002homoGel\u00ae\u4e3a\u7814\u7a76\u4eba\u5458\u63d0\u4f9b\u4e86\u5f3a\u5927\u7684\u5de5\u5177\uff0c\u5e2e\u52a9\u4ed6\u4eec\u66f4\u597d\u5730\u7406\u89e3TME\u7684\u590d\u6742\u6027\u53ca\u5176\u5728\u764c\u75c7\u8fdb\u5c55\u4e2d\u7684\u4f5c\u7528\u3002\u6b64\u5916\uff0chomoGel\u00ae\u5728\u7ec4\u7ec7\u5de5\u7a0b\u548c\u518d\u751f\u533b\u5b66\u4e2d\u7684\u5e94\u7528\u4e3a\u63a8\u8fdb\u6cbb\u7597\u5f00\u53d1\u548c\u6539\u5584\u60a3\u8005\u9884\u540e\u5e26\u6765\u4e86\u5de8\u5927\u7684\u5e0c\u671b\u3002\u533b\u7597\u4fdd\u5065\u7684\u672a\u6765\u5728\u4e8e\u590d\u5236\u4eba\u4f53\u7684\u5929\u7136\u7cfb\u7edf\uff0c\u800chomoGel\u00ae\u6b63\u5904\u5728\u8fd9\u573a\u9769\u547d\u7684\u524d\u6cbf\u3002<\/p><p><strong>\u53c2\u8003\u8d44\u6599<\/strong><\/p><ul><li>Chaffer, C.L., &amp; Weinberg, R.A. (2011). A perspective on cancer cell metastasis. <em>Science<\/em>, 331(6024), 1559-1564.<\/li><li>Cox, T.R., &amp; Erler, J.T. (2011). Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer. <em>Dis Model Mech<\/em>., 4(2), 165-178.<\/li><li>Hanahan, D., &amp; Folkman, J. (1996). Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. <em>Cell<\/em>, 86(3), 353-364.<\/li><li>Hanahan, D., &amp; Weinberg, R.A. (2011). Hallmarks of cancer: the next generation. <em>Cell<\/em>, 144(5), 646-674.<\/li><li>Kalluri, R. (2016). The biology and function of fibroblasts in cancer. <em>Nature Reviews Cancer<\/em>, 16(9), 582-598.<\/li><li>Nieto, M.A., Huang, R.Y., Jackson, R.A., &amp; Thiery, J.P. (2016). Epithelial mesenchymal transition: the role in cancer progression and metastasis. <em>Nature Reviews Cancer<\/em>, 16(5), 305- 320.<\/li><li>Noy, R., &amp; Pollard, J.W. (2014). Tumor associated macrophages: from mechanisms to therapy. <em>Immunity<\/em>, 41(1), 49-61.<\/li><li>Whiteside, T.L. (2008). The tumor microenvironment and its role in promoting tumor growth. <em>Oncogene<\/em>, 27(45), 5904-5912.<\/li><li>Chen, Z., Zhao, R., Shi, Z., Zhang, Z., &amp; Gao, W. (2021). 3D bioprinting of stem cell-laden scaffolds: Advancements in vascularization and tissue regeneration. <em>Biomaterials Science<\/em>, 9(11), 4080-4100.<\/li><li>Gao, L., McBeath, R., &amp; Chen, C.S. (2021). Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherin. <em>Science Advances<\/em>, 7(28), eabc5174.<\/li><li>Jang, Y., Kim, J., Kim, J.M., &amp; Lee, H. (2022). Human ECM-based scaffolds for tissue engineering and regenerative medicine: Recent advances and future perspectives. <em>Nature Reviews Bioengineering<\/em>, 3(1), 112-130.<\/li><li>Lau, C.L., Fitzpatrick, C., Shew, M., &amp; Zhang, Y. (2021). Influence of extracellular matrix composition and stiffness on iPSC differentiation into neural and mesenchymal lineages. <em>Stem Cell Research &amp; Therapy<\/em>, 12(1), 345-358.<\/li><li>Liang, X., Li, X., Zhang, S., &amp; Luo, J. (2022). Advanced human-derived ECM materials in bioprinting: Applications and innovations in regenerative medicine. <em>Frontiers in Bioengineering and Biotechnology<\/em>, 10, 834958.<\/li><li>Yin, L., Huang, W., Wu, T., &amp; Li, X. (2021). Mimicking the in vivo human microenvironment using 3D-bioprinted hydrogels for stem cell-based tissue regeneration. <em>Advanced Materials<\/em>, 33(12), e2006379.<\/li><li>Zhang, H., Zhao, L., Wang, X., &amp; Chen, Z. (2022). Human-specific ECM hydrogels enhance stem cell function and tissue regeneration. <em>Advanced Healthcare Materials<\/em>, 11(3), e2101583.<\/li><li>Zhao, R., Ding, J., &amp; Ma, P.X. (2021). Recent progress in tissue engineering scaffolds for regenerative medicine. <em>Advanced Functional Materials<\/em>, 31(6), 2006992.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u63ed\u5f00\u764c\u75c7\u7684\u590d\u6742\u9762\u7eb1\uff1a\u4ece\u53d8\u5f02\u7ec6\u80de\u5230\u52a8\u6001\u75be\u75c5 \u751f\u547d\u79d1\u5b66\u9ad8\u7ea7\u79d1\u5b66\u5bb6Djeda Belharazem\u535a\u58eb djeda. <a class=\"read-more\" href=\"https:\/\/biomex.de\/zh-hans\/%e6%8f%ad%e5%bc%80%e7%99%8c%e7%97%87%e7%9a%84%e5%a4%8d%e6%9d%82%e9%9d%a2%e7%ba%b1-%e4%bb%8e%e5%8f%98%e5%bc%82%e7%bb%86%e8%83%9e%e5%88%b0%e5%8a%a8%e6%80%81%e7%96%be%e7%97%85\/\">Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":17862,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-17914","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u63ed\u5f00\u764c\u75c7\u7684\u590d\u6742\u9762\u7eb1\uff1a\u4ece\u53d8\u5f02\u7ec6\u80de\u5230\u52a8\u6001\u75be\u75c5 - BIOMEX<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomex.de\/zh-hans\/%e6%8f%ad%e5%bc%80%e7%99%8c%e7%97%87%e7%9a%84%e5%a4%8d%e6%9d%82%e9%9d%a2%e7%ba%b1-%e4%bb%8e%e5%8f%98%e5%bc%82%e7%bb%86%e8%83%9e%e5%88%b0%e5%8a%a8%e6%80%81%e7%96%be%e7%97%85\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u63ed\u5f00\u764c\u75c7\u7684\u590d\u6742\u9762\u7eb1\uff1a\u4ece\u53d8\u5f02\u7ec6\u80de\u5230\u52a8\u6001\u75be\u75c5 - BIOMEX\" \/>\n<meta property=\"og:description\" content=\"\u63ed\u5f00\u764c\u75c7\u7684\u590d\u6742\u9762\u7eb1\uff1a\u4ece\u53d8\u5f02\u7ec6\u80de\u5230\u52a8\u6001\u75be\u75c5 \u751f\u547d\u79d1\u5b66\u9ad8\u7ea7\u79d1\u5b66\u5bb6Djeda Belharazem\u535a\u58eb djeda. 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