{"id":19786,"date":"2023-02-01T19:46:08","date_gmt":"2023-02-01T18:46:08","guid":{"rendered":"https:\/\/biomex.de\/?page_id=19786"},"modified":"2025-10-22T16:44:36","modified_gmt":"2025-10-22T14:44:36","slug":"immunogenitaet-und-immunotoxizitaet","status":"publish","type":"page","link":"https:\/\/biomex.de\/de\/life-sciences\/anwendungsbereiche\/immunogenitaet-und-immunotoxizitaet\/","title":{"rendered":"Immunogenit\u00e4t und Immunotoxizit\u00e4t"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"19786\" class=\"elementor elementor-19786 elementor-8294\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6963371 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"6963371\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9615090\" data-id=\"9615090\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-36ec49a elementor-widget elementor-widget-template\" data-id=\"36ec49a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"template.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-template\">\n\t\t\t\t\t<div data-elementor-type=\"section\" data-elementor-id=\"3732\" class=\"elementor elementor-3732\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-16dfb095 elementor-section-height-min-height elementor-section-items-bottom elementor-section-full_width elementor-section-height-default\" data-id=\"16dfb095\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-168bd6d2\" data-id=\"168bd6d2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-6c78d237 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"6c78d237\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-55a6dd30\" data-id=\"55a6dd30\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-17529196\" data-id=\"17529196\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-52ef323 elementor-absolute animated-fast elementor-hidden-tablet_extra elementor-hidden-tablet elementor-hidden-mobile_extra elementor-hidden-mobile elementor-view-default elementor-invisible elementor-widget elementor-widget-icon\" data-id=\"52ef323\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_effect&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:3,&quot;sizes&quot;:[]},&quot;_animation&quot;:&quot;slideInDown&quot;,&quot;motion_fx_translateY_affectedRange&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:0,&quot;end&quot;:100}},&quot;motion_fx_devices&quot;:[&quot;desktop&quot;,&quot;laptop&quot;,&quot;tablet_extra&quot;,&quot;tablet&quot;,&quot;mobile_extra&quot;,&quot;mobile&quot;]}\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div 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data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_effect&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:3,&quot;sizes&quot;:[]},&quot;_animation&quot;:&quot;slideInDown&quot;,&quot;motion_fx_translateY_affectedRange&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:0,&quot;end&quot;:100}},&quot;motion_fx_devices&quot;:[&quot;desktop&quot;,&quot;laptop&quot;,&quot;tablet_extra&quot;,&quot;tablet&quot;,&quot;mobile_extra&quot;,&quot;mobile&quot;]}\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div 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data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_effect&quot;:&quot;yes&quot;,&quot;motion_fx_translateY_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:3,&quot;sizes&quot;:[]},&quot;_animation&quot;:&quot;slideInDown&quot;,&quot;motion_fx_translateY_affectedRange&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:0,&quot;end&quot;:100}},&quot;motion_fx_devices&quot;:[&quot;desktop&quot;,&quot;laptop&quot;,&quot;tablet_extra&quot;,&quot;tablet&quot;,&quot;mobile_extra&quot;,&quot;mobile&quot;]}\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<i aria-hidden=\"true\" class=\"icon 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class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-1c83f26\" data-id=\"1c83f26\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-276a7f0 elementor-nav-menu__align-center elementor-nav-menu--dropdown-none elementor-hidden-mobile elementor-widget elementor-widget-nav-menu\" data-id=\"276a7f0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;layout&quot;:&quot;horizontal&quot;,&quot;submenu_icon&quot;:{&quot;value&quot;:&quot;&lt;i class=\\&quot;fas fa-caret-down\\&quot; aria-hidden=\\&quot;true\\&quot;&gt;&lt;\\\/i&gt;&quot;,&quot;library&quot;:&quot;fa-solid&quot;}}\" data-widget_type=\"nav-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<nav aria-label=\"Menu\" class=\"elementor-nav-menu--main elementor-nav-menu__container elementor-nav-menu--layout-horizontal e--pointer-none\">\n\t\t\t\t<ul id=\"menu-1-276a7f0\" class=\"elementor-nav-menu\"><li class=\"menu-item menu-item-type-custom menu-item-object-custom menu-item-16191\"><a href=\"#moi\" class=\"elementor-item elementor-item-anchor\">Immunogenit\u00e4t<\/a><\/li>\n<li class=\"menu-item menu-item-type-custom menu-item-object-custom menu-item-16192\"><a href=\"#moi2\" class=\"elementor-item elementor-item-anchor\">Immunotoxizit\u00e4t<\/a><\/li>\n<li class=\"menu-item menu-item-type-custom menu-item-object-custom menu-item-16193\"><a href=\"#panels\" class=\"elementor-item elementor-item-anchor\">Panels<\/a><\/li>\n<li class=\"menu-item menu-item-type-custom menu-item-object-custom menu-item-16194\"><a href=\"#services\" class=\"elementor-item elementor-item-anchor\">Dienstleistungen<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul 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tabindex=\"-1\">Dienstleistungen<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6697650 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6697650\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a4c010e\" data-id=\"a4c010e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f94a047 elementor-widget elementor-widget-spacer\" data-id=\"f94a047\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a20364 elementor-widget elementor-widget-heading\" data-id=\"7a20364\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Immunogenit\u00e4t und Immunotoxizit\u00e4t<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2cf68d5 elementor-widget elementor-widget-spacer\" data-id=\"2cf68d5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-ccc7af3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ccc7af3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e7b5f60\" data-id=\"e7b5f60\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-efa8078\" data-id=\"efa8078\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-621fb6d elementor-widget elementor-widget-text-editor\" data-id=\"621fb6d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Immunogenit\u00e4t und Immunotoxizit\u00e4t stellen potenzielle Herausforderungen bei der Entwicklung neuer Biotherapeutika, Impfstoffe sowie Zell- und Gentherapien dar. Diese Themen stehen daher im Fokus intensiver Studien und Diskussionen seitens der Regulierungsbeh\u00f6rden und der wissenschaftlichen Gemeinschaft.<\/p><p>Unter Immunogenit\u00e4t versteht man die F\u00e4higkeit einer Substanz, eine Immunantwort auszul\u00f6sen. Immunotoxizit\u00e4t hingegen bezeichnet die F\u00e4higkeit einer Substanz, sch\u00e4dliche Wirkungen im Immunsystem oder anderen K\u00f6rpersystemen hervorzurufen, die durch eine Fehlfunktion des Immunsystems bedingt sind.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-b7691e8 elementor-widget elementor-widget-spacer\" data-id=\"b7691e8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bc5f7e0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bc5f7e0\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-95c81be\" data-id=\"95c81be\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3869302 elementor-widget elementor-widget-spacer\" data-id=\"3869302\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7f549cf elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7f549cf\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-9996d1e\" data-id=\"9996d1e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dd0ca4e elementor-widget elementor-widget-heading\" data-id=\"dd0ca4e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Welche Rolle spielen Immunogenit\u00e4t und Immunotoxizit\u00e4t bei der Entwicklung neuartiger Proteintherapeutika?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e27d0cf\" data-id=\"e27d0cf\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-ba17734 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ba17734\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-68ec5f2\" data-id=\"68ec5f2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-002fbbc elementor-widget elementor-widget-text-editor\" data-id=\"002fbbc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Die Bewertung von Immunogenit\u00e4t und Immunotoxizit\u00e4t bei neuartigen Proteintherapeutika spielt eine zentrale Rolle, um deren Sicherheit und Wirksamkeit zu gew\u00e4hrleisten. Dabei stehen Entwickler vor diversen Herausforderungen, wie den Variationen immunologischer Reaktionen zwischen unterschiedlichen Bev\u00f6lkerungsgruppen, den altersbedingten Ver\u00e4nderungen der Immunogenit\u00e4t von Impfstoffen sowie der generellen Eignungslosigkeit von Tiermodellen zur Vorhersage von Immunantworten beim Menschen.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-60fd280\" data-id=\"60fd280\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-ce8d6c2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ce8d6c2\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-a56cfed\" data-id=\"a56cfed\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d9fa616 elementor-widget elementor-widget-image\" data-id=\"d9fa616\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"643\" src=\"https:\/\/biomex.de\/wp-content\/uploads\/BIOMEX_immunogenicity_graphic-1.png\" class=\"attachment-large size-large wp-image-6024\" alt=\"Immuno\" srcset=\"https:\/\/biomex.de\/wp-content\/uploads\/BIOMEX_immunogenicity_graphic-1.png 800w, https:\/\/biomex.de\/wp-content\/uploads\/BIOMEX_immunogenicity_graphic-1-300x241.png 300w, https:\/\/biomex.de\/wp-content\/uploads\/BIOMEX_immunogenicity_graphic-1-768x617.png 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-57d2d65\" data-id=\"57d2d65\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7e1957e elementor-widget elementor-widget-text-editor\" data-id=\"7e1957e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>W\u00e4hrend Immunotoxizit\u00e4t in der Regel eine unerw\u00fcnschte Nebenwirkung therapeutischer Ans\u00e4tze darstellt, kann Immunogenit\u00e4t sowohl eine gew\u00fcnschte als auch eine unerw\u00fcnschte Wirkung bei neuartigen Proteintherapeutika sein:<\/p><ul><li><strong>Gew\u00fcnschte Immunogenit\u00e4t<\/strong> ist ein zentraler Aspekt der Wirksamkeit von Impfstoffen. Durch die Injektion des gew\u00fcnschten Antigens wird eine gezielte Immunantwort ausgel\u00f6st, die einen Schutz gegen den aktiven Krankheitserreger aufbaut.<br \/><br \/><\/li><li><strong>Unerw\u00fcnschte Immunogenit\u00e4t<\/strong> bezeichnet hingegen eine ungewollte Immunreaktion gegen Proteintherapeutika. Diese f\u00fchrt h\u00e4ufig zur Bildung von Anti-Drug-Antik\u00f6rpern (ADAs), die inaktivierenden oder neutralisierenden Eigenschaften gegen\u00fcber dem Therapeutikum aufweisen k\u00f6nnen.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-40dafcd elementor-hidden-mobile elementor-widget elementor-widget-spacer\" data-id=\"40dafcd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-817df57 elementor-widget elementor-widget-text-editor\" data-id=\"817df57\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Aufgrund der potenziellen Risiken unerw\u00fcnschter Immunogenit\u00e4t erwarten regulatorische Beh\u00f6rden, dass Entwickler von nicht-vakzinenbasierten Biologika validierte Immunogenit\u00e4tsassays einsetzen, um das Risiko der ADA-Bildung in den klinischen Entwicklungsphasen zu erkennen und zu charakterisieren.<\/p><p>W\u00e4hrend der pr\u00e4klinischen Bewertung von Immunogenit\u00e4t und Immunotoxizit\u00e4t kann eine fr\u00fchzeitige Charakterisierung der angeborenen und adaptiven Immunantwort gegen neuartige Proteintherapeutika dazu beitragen, Entwicklungsrisiken zu minimieren. Dar\u00fcber hinaus k\u00f6nnen dabei wertvolle Einblicke in den Wirkmechanismus sowie Hinweise zur Patientensegmentierung in den klinischen Phasen gewonnen werden.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-51a0ea4 elementor-widget elementor-widget-spacer\" data-id=\"51a0ea4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-891b9e2 elementor-widget elementor-widget-menu-anchor\" data-id=\"891b9e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"moi\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d8c111c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d8c111c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b15af52\" data-id=\"b15af52\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-53ee933 elementor-widget elementor-widget-spacer\" data-id=\"53ee933\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-bbe6a61 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bbe6a61\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-352231e\" data-id=\"352231e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-72f91d2 elementor-widget elementor-widget-heading\" data-id=\"72f91d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Was sind die Mechanismen der Immunogenit\u00e4t?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-189fdd7\" data-id=\"189fdd7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-ce52bf1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ce52bf1\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-f1a64af\" data-id=\"f1a64af\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5e9d24f elementor-widget elementor-widget-text-editor\" data-id=\"5e9d24f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Immunogenit\u00e4t ist ein Mechanismus, der sowohl Zellen des angeborenen Immunsystems, wie Monozyten, Makrophagen, NK-Zellen, Mastzellen und Neutrophile, als auch Zellen des adaptiven Immunsystems, wie Makrophagen, dendritische Zellen, T-Helferzellen, zytotoxische T-Zellen, regulatorische T-Zellen und B-Zellen, involviert. Ein wichtiger Einflussfaktor auf die Immunantwort ist das HLA-Profil eines Individuums. Daher ist es unerl\u00e4sslich, Zellen von Spendern mit einem HLA-Profil zu untersuchen, das die Zielpopulation repr\u00e4sentiert, um Immunogenit\u00e4ts-Assays pr\u00e4zise zu entwickeln.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-13ec156\" data-id=\"13ec156\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-313d097 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"313d097\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-a61fb54\" data-id=\"a61fb54\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5b1aa66 elementor-widget-mobile__width-inherit elementor-widget elementor-widget-image\" data-id=\"5b1aa66\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/biomex.de\/wp-content\/uploads\/elementor\/thumbs\/BIOMEX_immunogenicity_graphic-1-6-qr09rf97fy71zm8d1ml1i76393s0ohn2zljvnb2urg.png\" title=\"BIOMEX_immunogenicity_graphic-1\" alt=\"BIOMEX_immunogenicity_graphic-1\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d7fd70a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d7fd70a\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fb0c2de\" data-id=\"fb0c2de\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0d80404 elementor-arrows-position-outside elementor--h-position-center elementor--v-position-middle elementor-widget elementor-widget-slides\" data-id=\"0d80404\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;navigation&quot;:&quot;arrows&quot;,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;autoplay_speed&quot;:5000,&quot;infinite&quot;:&quot;yes&quot;,&quot;transition&quot;:&quot;slide&quot;,&quot;transition_speed&quot;:500}\" data-widget_type=\"slides.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper\">\n\t\t\t\t\t<div class=\"elementor-slides-wrapper elementor-main-swiper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Slides\" dir=\"ltr\" data-animation=\"\">\n\t\t\t\t<div class=\"swiper-wrapper elementor-slides\">\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-repeater-item-9c889a7 swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\" ><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">Das adaptive Immunsystem<\/div><div class=\"elementor-slide-description\">Das adaptive Immunsystem basiert auf der Erkennung von Epitopen (den Fragmenten eines fremden Proteins, die von Zellen verarbeitet werden) durch CD4+ T-Helferzellen. Diese Epitope werden auf der Zelloberfl\u00e4che von HLAs pr\u00e4sentiert. Alle Zellen pr\u00e4sentieren Fragmente der innerhalb der Zellen exprimierten Proteine \u00fcber HLA-Klasse I. Daher spielt HLA-Klasse I eine entscheidende Rolle bei der Erkennung von Zellen, die mit intrazellul\u00e4ren Pathogenen wie Viren infiziert sind.\nIm Gegensatz dazu besitzen bestimmte Immunzellen, die sogenannten antigenpr\u00e4sentierenden Zellen (APCs), darunter Makrophagen und dendritische Zellen, die F\u00e4higkeit, fremde Proteine aus der Umgebung der Zelle zu erkennen, aufzunehmen und \u00fcber HLA-Klasse II zu pr\u00e4sentieren. Diese Pr\u00e4sentation ist essenziell f\u00fcr die Erkennung extrazellul\u00e4rer Pathogene.\nCD4+ T-Helferzellen erkennen die kombinierte Struktur des HLA-Epitop-Komplexes \u00fcber den T-Zell-Rezeptor (TCR) und initiieren daraufhin die Immunreaktion. Diese Aktivierung f\u00fchrt entweder zur Stimulation von CD8+ T-Zytotoxischen Zellen, die infizierte Zellen durch das Bilden von Poren in deren Zellmembran eliminieren, oder zur Aktivierung von B-Zellen, die spezifische Antik\u00f6rper gegen das Epitop produzieren. Diese Antik\u00f6rper neutralisieren den Erreger oder die Fremdsubstanz und erm\u00f6glichen deren anschlie\u00dfende Phagozytose.\n<\/div><\/div><\/div><\/div><div class=\"elementor-repeater-item-44cfeb7 swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\" ><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">Das angeborene Immunsystem<\/div><div class=\"elementor-slide-description\">Die angeborene Immunantwort ist die erste Verteidigungslinie des K\u00f6rpers gegen fremde Substanzen. Diese werden durch Rezeptoren auf der Oberfl\u00e4che von Makrophagen und NK-Zellen erkannt (z. B. Pathogen-Erkennungs-Rezeptoren, PRRs, wie die Toll-like-Rezeptoren, TLR). Diese Rezeptoren induzieren die Produktion proinflammatorischer Zytokine und Molek\u00fcle, die die Rekrutierung phagozytierender Zellen wie Neutrophile f\u00f6rdern. Dieser Prozess f\u00fchrt letztlich zur Aktivierung des adaptiven Immunsystems.<\/div><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-prev\" role=\"button\" tabindex=\"0\" aria-label=\"Vorheriger Slide\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"eicon-chevron-left\"><\/i>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-next\" role=\"button\" tabindex=\"0\" aria-label=\"N\u00e4chster Slide\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"eicon-chevron-right\"><\/i>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b6b315 elementor-widget elementor-widget-spacer\" data-id=\"5b6b315\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-530ffc8 elementor-section-full_width elementor-section-height-min-height elementor-section-height-default elementor-section-items-middle\" data-id=\"530ffc8\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9301bd1\" data-id=\"9301bd1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2ff0445 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2ff0445\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b1f8221\" data-id=\"b1f8221\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1030b71 elementor-widget elementor-widget-spacer\" data-id=\"1030b71\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9201fe6 elementor-widget elementor-widget-heading\" data-id=\"9201fe6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Immunogenit\u00e4t in Biotherapeutika<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-44a1838 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"44a1838\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-ebdf7c7\" data-id=\"ebdf7c7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d1cd65e elementor-widget elementor-widget-image\" data-id=\"d1cd65e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"720\" src=\"https:\/\/biomex.de\/wp-content\/uploads\/biomex-lifescience-application-immuno.png\" class=\"attachment-large size-large wp-image-6869\" alt=\"\" srcset=\"https:\/\/biomex.de\/wp-content\/uploads\/biomex-lifescience-application-immuno.png 800w, https:\/\/biomex.de\/wp-content\/uploads\/biomex-lifescience-application-immuno-300x270.png 300w, https:\/\/biomex.de\/wp-content\/uploads\/biomex-lifescience-application-immuno-768x691.png 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-4485307\" data-id=\"4485307\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a740fce elementor-widget elementor-widget-text-editor\" data-id=\"a740fce\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Genau dieser zweite, HLA-Klasse-II-vermittelte Mechanismus f\u00fchrt zur Bildung von Anti-Drug-Antik\u00f6rpern (ADAs), was sowohl eine reduzierte Wirksamkeit von Biotherapeutika als auch andere unerw\u00fcnschte Ereignisse wie \u00dcberempfindlichkeitsreaktionen und eine erh\u00f6hte Clearance des therapeutischen Produkts zur Folge hat.<\/p><p>Da T-Zell-Rezeptoren (TCRs) den HLA-Epitop-Komplex erkennen, l\u00e4sst sich nachvollziehen, warum bestimmte HLA-Allele eine Rolle bei der Entwicklung von ADAs bei Patienten mit Multipler Sklerose und rheumatoider Arthritis spielen. Aus diesem Grund ist es wichtig, Biotherapeutika mit einer repr\u00e4sentativen Probe von Immunzellen (z. B. peripheren mononukle\u00e4ren Blutzellen, PBMCs) zu testen, die die h\u00e4ufigsten HLA-Klasse-II-Allele oder Haplotypen (eine Gruppe von Allelen, die gemeinsam von einem Elternteil vererbt werden) der Zielpopulation pr\u00e4sentieren.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-4391a14 elementor-hidden-mobile elementor-widget elementor-widget-spacer\" data-id=\"4391a14\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a6062c8 elementor-widget elementor-widget-text-editor\" data-id=\"a6062c8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Ein solches Screening erm\u00f6glicht eine fr\u00fchzeitige Identifikation potenzieller Immunogenit\u00e4tsrisiken und tr\u00e4gt dazu bei, die Sicherheit und Wirksamkeit von Biotherapeutika f\u00fcr die jeweilige Zielgruppe zu gew\u00e4hrleisten.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f6f9ac2 elementor-widget elementor-widget-spacer\" data-id=\"f6f9ac2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-e7c8e4a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e7c8e4a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-6bb5437\" data-id=\"6bb5437\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ef1bf57 elementor-widget elementor-widget-heading\" data-id=\"ef1bf57\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">H\u00e4ufige Ursachen f\u00fcr Immunogenit\u00e4t umfassen:<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b75d815 elementor-widget elementor-widget-eael-feature-list\" data-id=\"b75d815\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"eael-feature-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"-icon-position-left -tablet-icon-position-left -mobile-icon-position-left\">\n\t\t\t<ul id=\"eael-feature-list-b75d815\" class=\"eael-feature-list-items circle stacked  eael-feature-list-vertical\" data-layout-tablet=\"vertical\" data-layout-mobile=\"vertical\">\n\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-9b80388\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-0\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">Die HLA-Allele des Patienten<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-7114bc6\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-1\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">Die Aminos\u00e4urestruktur des Biotherapeutikums<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-14b8d97\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-2\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">M\u00f6gliche Aggregation des Biotherapeutikums<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-6c186e1\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-3\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">Chemische Modifikationen oder Abbauprozesse<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-6105ba3\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-4\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">Der Verabreichungsweg<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-4591c1e\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-5\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">M\u00f6gliche Vorerkrankungen des Patienten<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-d51981e\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-6\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">Verunreinigungen und Kontaminationen<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-50c6838\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-7\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">Formulierung und Dosierung<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-29afb95\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-8\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">Der Wirkmechanismus (z. B. intra- oder extrazellul\u00e4re Zielstrukturen)<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-104e1ad\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-9\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">Posttranslationale Modifikationen (PTMs) wie Glykosylierung und PEGylierung<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-599f06c\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-10\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">Das Vorhandensein von Komponenten tierischen Ursprungs<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-5fc7462\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-11\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">Das Vorhandensein tierischer Sequenzen in der Struktur des Biotherapeutikums<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<\/ul>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a10ea4 elementor-widget elementor-widget-spacer\" data-id=\"7a10ea4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d0d85e3 elementor-widget elementor-widget-text-editor\" data-id=\"d0d85e3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Die Bewertung der Immunogenit\u00e4t eines Biotherapeutikums kann bereits in der pr\u00e4klinischen Entwicklungsphase erfolgen. Dies geschieht durch eine <strong>in silico<\/strong>-Analyse der Epitope im Biotherapeutikum, eine zellbasierte Untersuchung der ausgew\u00e4hlten Epitope auf Immunzellen, die die h\u00e4ufigsten HLA-Klasse-II-Varianten abdecken, sowie durch <strong>in vitro<\/strong>-Immunogenit\u00e4tsassays, die Antik\u00f6rperbindung und neutralisierende Reaktionen vorhersagen.<br \/>W\u00e4hrend der klinischen Entwicklung kann das Vorhandensein von Anti-Drug-Antik\u00f6rpern (ADAs) durch validierte Nachweisverfahren in Blutproben von Patienten best\u00e4tigt werden.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9bad38e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9bad38e\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3394d73\" data-id=\"3394d73\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f13310e elementor-widget elementor-widget-spacer\" data-id=\"f13310e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce7026c elementor-widget elementor-widget-heading\" data-id=\"ce7026c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Immunogenit\u00e4t in Zell- und Gentherapien sowie Impfstoffen<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-01d775f elementor-widget elementor-widget-text-editor\" data-id=\"01d775f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>W\u00e4hrend die adaptive Immunantwort, die durch HLA-Klasse-II-Molek\u00fcle vermittelt wird, eine zentrale Rolle bei der Entwicklung von Immunogenit\u00e4t gegen Biotherapeutika (unerw\u00fcnschte Immunogenit\u00e4t) und Impfstoffe (erw\u00fcnschte Immunogenit\u00e4t) spielt, ist die HLA-Klasse-I-vermittelte Immunantwort entscheidend f\u00fcr die Entwicklung von Zell- und Gentherapien sowie Impfstoffen.<\/strong><\/p><p>Zelltherapien umfassen Anwendungen, bei denen Zellen expandiert und gesch\u00e4digtem Gewebe wieder zugef\u00fchrt werden. Bei allogenen Zelltherapien ist zu ber\u00fccksichtigen, dass Unterschiede in den polymorphen Regionen endogener Proteine des Spenders oder die Expression unterschiedlicher HLA-Allele dazu f\u00fchren k\u00f6nnen, dass neue Epitope auf HLA-Klasse-I-Molek\u00fclen pr\u00e4sentiert werden. Diese werden daraufhin von NK-Zellen oder CD8+ T-Zytotoxischen Zellen eliminiert.<\/p><p>Gentherapien sind Anwendungen, bei denen Zellen entweder in vivo oder ex vivo genetisch modifiziert werden. Analog zu Arzneimitteln f\u00fcr neuartige Therapien (ATMPs), bei denen genetische Manipulationen an autologen oder allogenen Zellen durchgef\u00fchrt werden, k\u00f6nnen neue Sequenzen und\/oder Epitope eingef\u00fchrt werden. Diese neu gebildeten Epitope werden ebenfalls von HLA-Klasse-I-Molek\u00fclen pr\u00e4sentiert und potenziell von NK-Zellen oder CD8+ T-Zytotoxischen Zellen eliminiert.<\/p><p>Obwohl die Immunantwort auf Impfstoffe zu einem gro\u00dfen Teil von der durch HLA-Klasse-II vermittelte adaptive Immunantwort abh\u00e4ngt, um neutralisierende Antik\u00f6rper zu generieren, ist die Aktivierung von CD8+ T-Zytotoxischen Zellen verantwortlich f\u00fcr die Eliminierung infizierter Zellen bei viralen und anderen intrazellul\u00e4ren Pathogenen. Dies stoppt die Infektion. mRNA-Impfstoffe haben sich w\u00e4hrend der COVID-19-Pandemie als wesentliche Methode zur Bek\u00e4mpfung von Infektionen erwiesen und sich als schnell entwickelbare Impfstoffplattform gegen eine Vielzahl von Pathogenen etabliert. Ihre Wirksamkeit beruht darauf, dass pathogenabgeleitete Antigene in den Zellen der geimpften Person exprimiert werden. Daher ist die \u00dcberwachung der HLA-Klasse-I-vermittelten Immunantwort entscheidend, um einerseits einen ausreichenden Schutz gegen den Erreger sicherzustellen und andererseits Toxizit\u00e4ten an der Injektionsstelle zu vermeiden, die durch die CD8+ T-Zytotoxische Antwort auf antigenexprimierende Zellen des Impfstoffs hervorgerufen werden k\u00f6nnen.<\/p><p><strong>Es ist daher essenziell, die Immunogenit\u00e4t von Zell- und Gentherapien sowie Impfstoffen zu bewerten, indem sie an Immunzellen getestet werden, die die am h\u00e4ufigsten in der Zielpopulation vorkommenden HLA-Klasse-I-Molek\u00fcle repr\u00e4sentieren.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e033845 elementor-widget__width-auto elementor-mobile-align-left animated-slow elementor-invisible elementor-widget elementor-widget-button\" data-id=\"e033845\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;bounceIn&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-xs\" href=\"https:\/\/biomex.de\/de\/life-sciences\/anwendungsbereiche\/zell-und-gentherapie\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-arrow-short\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">ERFAHREN SIE MEHR \u00dcBER ZELL- UND GENTHERAPIEN<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8c5b20d elementor-widget elementor-widget-spacer\" data-id=\"8c5b20d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8b9111e elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"8b9111e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3dc3dc0\" data-id=\"3dc3dc0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b5b5619 elementor-widget elementor-widget-spacer\" data-id=\"b5b5619\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-ef3ba91 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ef3ba91\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3e50ac2\" data-id=\"3e50ac2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-462c0b8 elementor-align-center elementor-invisible elementor-widget elementor-widget-button\" data-id=\"462c0b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;pulse&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"mailto:sales@biomex.de\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Kontaktieren Sie unser Vertriebsteam! <\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-1e76544\" data-id=\"1e76544\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7d3b004 elementor-align-center elementor-widget__width-auto animated-slow elementor-invisible elementor-widget elementor-widget-button\" data-id=\"7d3b004\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;pulse&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/sampleshop.biomex.de\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Besuchen Sie unseren SampleShop<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-0a269ba elementor-widget__width-auto elementor-hidden-mobile elementor-widget elementor-widget-spacer\" data-id=\"0a269ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d388c05 elementor-widget elementor-widget-spacer\" data-id=\"d388c05\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1d69887 elementor-widget elementor-widget-menu-anchor\" data-id=\"1d69887\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"assays\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-723a778 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"723a778\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-bd82ab5\" data-id=\"bd82ab5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e3119e5 elementor-widget elementor-widget-spacer\" data-id=\"e3119e5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-b4c0511 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b4c0511\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-59e110c\" data-id=\"59e110c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7a22f44 elementor-widget elementor-widget-heading\" data-id=\"7a22f44\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Welche Assays werden f\u00fcr die Immunogenit\u00e4tspr\u00fcfung verwendet?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-5548f95\" data-id=\"5548f95\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-fd70b76 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fd70b76\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-1a7129e\" data-id=\"1a7129e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d5ef569 elementor-widget elementor-widget-text-editor\" data-id=\"d5ef569\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Die Entwicklung von Biotherapeutika, Biosimilars, Zell- und Gentherapien sowie Impfstoffen erfordert eine umfassende Analyse des Immunogenit\u00e4tsrisikos sowohl des Wirkstoffs als auch des Endprodukts. Die Bewertung des Immunogenit\u00e4tsrisikos basiert auf einer Vielzahl von Assays, die dazu beitragen, das Auftreten und die Ursachen der Immunogenit\u00e4t in Ihrem therapeutischen Ansatz zu verstehen und die optimale Strategie zu entwickeln.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-a5ad71a\" data-id=\"a5ad71a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3754aad elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3754aad\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-3e259b9\" data-id=\"3e259b9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-df3e447 elementor-widget elementor-widget-heading\" data-id=\"df3e447\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Zu den g\u00e4ngigen Assays f\u00fcr die pr\u00e4klinische Bewertung der Immunogenit\u00e4t geh\u00f6ren:<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3651c13 elementor-widget elementor-widget-spacer\" data-id=\"3651c13\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-12b19df elementor-widget elementor-widget-eael-feature-list\" data-id=\"12b19df\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-feature-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"-icon-position-left -tablet-icon-position-left -mobile-icon-position-left\">\n\t\t\t<ul id=\"eael-feature-list-12b19df\" class=\"eael-feature-list-items circle stacked  eael-feature-list-vertical\" data-layout-tablet=\"vertical\" data-layout-mobile=\"vertical\">\n\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-9b80388\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-0\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">In-silico-Epitop-Analysen<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-8c23147\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-1\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">In-vitro-Bindungsassays f\u00fcr HLA-Klasse-I- und HLA-Klasse-II-Molek\u00fcle<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-5e21634\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-2\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">Zellbasierte Immunogenit\u00e4tsassays, einschlie\u00dflich T-Zell-Proliferationsassays, DC:T-Zell-Stimulations- und Proliferationsassays sowie 2D- und 3D-Migrations- und Aktivierungsassays in komplexen Modellen<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-04903ba\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-3\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">In-vivo-Immunogenit\u00e4tsbewertung mit humanisierten Mausmodellen<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-f2b3395\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-4\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">Ex-vivo-Assays mit Plasma oder Vollblut zur Detektion anti-drug antibodies (ADA)<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<\/ul>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-a205480 elementor-widget elementor-widget-menu-anchor\" data-id=\"a205480\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"moi2\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9678c09 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9678c09\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e7f9a77\" data-id=\"e7f9a77\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-aa5f1bb elementor-widget elementor-widget-spacer\" data-id=\"aa5f1bb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-de71ba3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"de71ba3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-b9c5864\" data-id=\"b9c5864\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a6765dd elementor-widget elementor-widget-heading\" data-id=\"a6765dd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Was sind die Mechanismen der Immunotoxizit\u00e4t?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-d828026 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d828026\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-b6eb03b\" data-id=\"b6eb03b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ff909fe elementor-widget elementor-widget-text-editor\" data-id=\"ff909fe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Immunotoxizit\u00e4t beschreibt die F\u00e4higkeit einer Substanz, die humorale oder zellul\u00e4re Immunantwort zu beeintr\u00e4chtigen. Dies kann zu Immunsuppression f\u00fchren oder unn\u00f6tige Gewebesch\u00e4den verursachen, wie im Falle von \u00dcberempfindlichkeitsreaktionen, Autoimmunit\u00e4t oder chronischen Entz\u00fcndungen. Immunotoxizit\u00e4t wird in <strong>on-target<\/strong>&#8211; und <strong>off-target-Immunotoxizit\u00e4t<\/strong> unterteilt.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e32977e\" data-id=\"e32977e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-e505bdb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e505bdb\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-4520328\" data-id=\"4520328\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7bcc1a4 elementor-widget elementor-widget-text-editor\" data-id=\"7bcc1a4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Immunomodulatory therapies as well as immune-based ATMPs such as CAR-T Cell Therapies are known to potentially induce CRS as a consequence of cell damage on- and off-target. It is therefore important to monitor the possibile occurence of immunotoxic effects in order to implement appropriate strategies during early development.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-b460020\" data-id=\"b460020\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-1e320b3 elementor-widget elementor-widget-eael-adv-accordion\" data-id=\"1e320b3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-adv-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t            <div class=\"eael-adv-accordion\" id=\"eael-adv-accordion-1e320b3\" data-scroll-on-click=\"no\" data-scroll-speed=\"300\" data-accordion-id=\"1e320b3\" data-accordion-type=\"accordion\" data-toogle-speed=\"300\">\n            <div class=\"eael-accordion-list\">\n\t\t\t\t\t<div id=\"on-target-immunotoxizitt\" class=\"elementor-tab-title eael-accordion-header active-default\" tabindex=\"0\" data-tab=\"1\" aria-controls=\"elementor-tab-content-3161\"><span class=\"eael-accordion-tab-title\">On-target-Immunotoxizit\u00e4t<\/span><i aria-hidden=\"true\" class=\"fa-toggle icon icon-signet-left-colored\"><\/i><\/div><div id=\"elementor-tab-content-3161\" class=\"eael-accordion-content clearfix active-default\" data-tab=\"1\" aria-labelledby=\"on-target-immunotoxizitt\"><p>Die <strong>on-target-Immunotoxizit\u00e4t<\/strong> wird h\u00e4ufig durch immunmodulatorische monoklonale Antik\u00f6rper (mAb) hervorgerufen. Sie resultiert aus einer \u00fcberm\u00e4\u00dfigen oder verl\u00e4ngerten Aktivit\u00e4t des Antik\u00f6rpers, der an das gew\u00fcnschte Zielantigen oder die Zielzelle\/-mediator bindet. Dies kann zur Modulation eines Ziels f\u00fchren, das mehrere immunologische Funktionen hat, darunter auch solche ohne therapeutischen Nutzen, und somit Nebenwirkungen hervorrufen.<\/p><\/div>\n\t\t\t\t\t<\/div><div class=\"eael-accordion-list\">\n\t\t\t\t\t<div id=\"off-target-immunotoxizitt\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"2\" aria-controls=\"elementor-tab-content-3162\"><span class=\"eael-accordion-tab-title\">Off-target-Immunotoxizit\u00e4t<\/span><i aria-hidden=\"true\" class=\"fa-toggle icon icon-signet-left-colored\"><\/i><\/div><div id=\"elementor-tab-content-3162\" class=\"eael-accordion-content clearfix\" data-tab=\"2\" aria-labelledby=\"off-target-immunotoxizitt\"><p>Die <strong>off-target-Immunotoxizit\u00e4t<\/strong> tritt h\u00e4ufig auf, wenn mAb Epitopen erkennen, die von nicht-immunologischen Zellen oder anderen Zellen exprimiert werden, die nicht als therapeutische Ziele vorgesehen sind.<\/p><\/div>\n\t\t\t\t\t<\/div><div class=\"eael-accordion-list\">\n\t\t\t\t\t<div id=\"das-zytokinfreisetzungssyndrom-crs\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"3\" aria-controls=\"elementor-tab-content-3163\"><span class=\"eael-accordion-tab-title\">Das Zytokinfreisetzungssyndrom (CRS)<\/span><i aria-hidden=\"true\" class=\"fa-toggle icon icon-signet-left-colored\"><\/i><\/div><div id=\"elementor-tab-content-3163\" class=\"eael-accordion-content clearfix\" data-tab=\"3\" aria-labelledby=\"das-zytokinfreisetzungssyndrom-crs\"><p>Das <strong>Zytokinfreisetzungssyndrom (CRS)<\/strong> stellt eine der schwerwiegendsten Folgen der Immunotoxizit\u00e4t dar und kann potenziell t\u00f6dliche Auswirkungen haben. CRS entsteht durch eine sogenannte Zytokinsturm-Reaktion, die als Folge einer normalen Immunantwort gegen Pathogene oder fremde Substanzen ausgel\u00f6st wird. W\u00e4hrend dieser Reaktion setzen aktivierte Makrophagen und dendritische Zellen Zytokine frei, um Lymphozyten zu rekrutieren und die Entz\u00fcndungsprozesse einzuleiten.<\/p><\/div>\n\t\t\t\t\t<\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1fa078f elementor-widget elementor-widget-spacer\" data-id=\"1fa078f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91213e0 elementor-widget elementor-widget-menu-anchor\" data-id=\"91213e0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"assays2\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-26ce9d2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"26ce9d2\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3f1415e\" data-id=\"3f1415e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-46d754b elementor-widget elementor-widget-spacer\" data-id=\"46d754b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-d5c24c0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d5c24c0\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-10b727b\" data-id=\"10b727b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b30fe79 elementor-widget elementor-widget-heading\" data-id=\"b30fe79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Welche Assays werden f\u00fcr die Immunotoxizit\u00e4tstests verwendet?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-46124ed elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"46124ed\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e932c9b\" data-id=\"e932c9b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4eb6857 elementor-widget elementor-widget-text-editor\" data-id=\"4eb6857\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Die Immunotoxizit\u00e4t ist eine der zentralen \u00dcberlegungen w\u00e4hrend der Auswahl von Leitstrukturen (Lead Selection) und der anschlie\u00dfenden Optimierung. Eine fr\u00fchzeitige Bewertung von On- und Off-Target-Toxizit\u00e4ten ist von entscheidender Bedeutung, um den Entwicklungsprozess zu entlasten und Risiken zu minimieren. Um die Immunotoxizit\u00e4t einer therapeutischen Strategie zu untersuchen, ist es essenziell, deren Wirkmechanismus zu verstehen und das klinisch akzeptable Risiko-Nutzen-Verh\u00e4ltnis f\u00fcr die Patient*innen abzuw\u00e4gen.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-75139da\" data-id=\"75139da\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-70a47ef elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"70a47ef\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-f3bc0b4\" data-id=\"f3bc0b4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-65b5913 elementor-widget elementor-widget-heading\" data-id=\"65b5913\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">G\u00e4ngige Assays zur Bewertung der Immunotoxizit\u00e4t umfassen:<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d2d485f elementor-widget elementor-widget-eael-feature-list\" data-id=\"d2d485f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-feature-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"-icon-position-left -tablet-icon-position-left -mobile-icon-position-left\">\n\t\t\t<ul id=\"eael-feature-list-d2d485f\" class=\"eael-feature-list-items circle stacked  eael-feature-list-vertical\" data-layout-tablet=\"vertical\" data-layout-mobile=\"vertical\">\n\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-9b80388\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-0\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\"><b>In-silico-Epitopanalysen:<\/b> Vorhersage potenzieller immunogener Epitopbereiche mithilfe computergest\u00fctzter Methoden.<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-8c23147\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-1\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\"><b>Zellbasierte Off-Target-Toxizit\u00e4tsbewertung mit prim\u00e4ren Zellen aus nicht-zielgerichteten Geweben:<\/b> Untersuchung unerw\u00fcnschter Effekte auf Gewebe, die nicht das Ziel der Therapie sind.<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-5e21634\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-2\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\"><b>Zellbasierte On-Target-Toxizit\u00e4tsbewertung von CRS (Cytokinfreisetzungssyndrom):<\/b> Analyse potenzieller \u00dcberreaktionen des Immunsystems auf die Therapie.<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-04903ba\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-3\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\"><b>In-vivo-Studien (abh\u00e4ngig von der Pharmakologie):<\/b> Untersuchung der Immuntoxizit\u00e4t in geeigneten Tiermodellen, wenn erforderlich.<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-f2b3395\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-4\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\"><b>Ex-vivo-Assays mit Plasma oder Vollblut zur Detektion von ADAs (Anti-Drug Antibodies):<\/b> \u00dcberpr\u00fcfung der Bildung von Antik\u00f6rpern gegen das Therapeutikum.<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<\/ul>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-27e7c72 elementor-widget elementor-widget-spacer\" data-id=\"27e7c72\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-737c491 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"737c491\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-40789dd\" data-id=\"40789dd\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b95b200 elementor-widget elementor-widget-menu-anchor\" data-id=\"b95b200\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"panels\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a320b92 elementor-widget elementor-widget-spacer\" data-id=\"a320b92\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-9f2c067 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9f2c067\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-8f8413f\" data-id=\"8f8413f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-392137b elementor-widget elementor-widget-heading\" data-id=\"392137b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Immunogenit\u00e4ts- und Immunotoxizit\u00e4tspanels<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-48efdc0\" data-id=\"48efdc0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3713f2a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3713f2a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-b8c24c0\" data-id=\"b8c24c0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-30b3555 elementor-widget elementor-widget-text-editor\" data-id=\"30b3555\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Die Immunogenit\u00e4ts- und Immunotoxizit\u00e4tspanels von BIOMEX wurden entwickelt, um die hausinterne Sicherheitspr\u00fcfung von gro\u00dfen Molek\u00fclen, Zelltherapien und Gentherapien w\u00e4hrend der pr\u00e4klinischen und klinischen Phasen zu unterst\u00fctzen. Die Panels sind so konfiguriert, dass sie das gesamte Spektrum der h\u00e4ufigsten HLA-Klasse-I- oder Klasse-II-Allele in der kaukasischen Bev\u00f6lkerung abbilden und sich ideal f\u00fcr erste Screening-Assays eignen. Panels zur Durchf\u00fchrung spezifischerer Assays mit besonderen Allelen k\u00f6nnen auf Anfrage zusammengestellt werden.<\/p><p>Die Immunogenit\u00e4ts- und Immunotoxizit\u00e4tspanels umfassen jeweils 100 Vials, bestehend aus 10 Vials \u00e0 20 Millionen lebensf\u00e4hige kryokonservierte PBMCs\/Vial\/Spender f\u00fcr 10 Spender. Die kryokonservierten PBMCs werden auf Sterilit\u00e4t, Serologie und Zellaktivierung getestet und vorab in einem T-Zell-Proliferationsassay sowie einem DC:T-Zell-Stimulationsassay auf ihre Leistung \u00fcberpr\u00fcft. Auf Anfrage k\u00f6nnen Daten zu Demografie, klinischer Vorgeschichte und h\u00e4matologischen Analysen vor\/nach dem Auftauen bereitgestellt werden.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-2c82764\" data-id=\"2c82764\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-d83831a elementor-widget elementor-widget-spacer\" data-id=\"d83831a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-5e6b83f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5e6b83f\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-3af0b9e\" data-id=\"3af0b9e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a2c9369 elementor-widget elementor-widget-heading\" data-id=\"a2c9369\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Folgende Panels sind verf\u00fcgbar:<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-14c2b4d elementor-widget elementor-widget-eael-adv-accordion\" data-id=\"14c2b4d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-adv-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t            <div class=\"eael-adv-accordion\" id=\"eael-adv-accordion-14c2b4d\" data-scroll-on-click=\"no\" data-scroll-speed=\"300\" data-accordion-id=\"14c2b4d\" data-accordion-type=\"accordion\" data-toogle-speed=\"300\">\n            <div class=\"eael-accordion-list\">\n\t\t\t\t\t<div id=\"immunosafe-hla1\" class=\"elementor-tab-title eael-accordion-header active-default\" tabindex=\"0\" data-tab=\"1\" aria-controls=\"elementor-tab-content-2171\"><span class=\"eael-accordion-tab-title\">ImmunoSafe\u2122-HLA1<\/span><i aria-hidden=\"true\" class=\"fa-toggle icon icon-signet-left-colored\"><\/i><\/div><div id=\"elementor-tab-content-2171\" class=\"eael-accordion-content clearfix active-default\" data-tab=\"1\" aria-labelledby=\"immunosafe-hla1\"><p>Dieses Panel enth\u00e4lt 10 verschiedene Spender, die so zusammengestellt sind, dass sie die h\u00e4ufigsten HLA-Klasse-I-Allele in der kaukasischen Bev\u00f6lkerung abdecken, und enth\u00e4lt oft auch einige der weniger h\u00e4ufigen Allele. ImmunoSafe\u2122-HLA1-Panels sind als Standardprodukte erh\u00e4ltlich und k\u00f6nnen am n\u00e4chsten Tag geliefert werden. Falls das Panel nicht auf Lager ist, betr\u00e4gt die Lieferzeit bis zu 3 Wochen.<\/p><\/div>\n\t\t\t\t\t<\/div><div class=\"eael-accordion-list\">\n\t\t\t\t\t<div id=\"immunosafe-hla2\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"2\" aria-controls=\"elementor-tab-content-2172\"><span class=\"eael-accordion-tab-title\">ImmunoSafe\u2122-HLA2<\/span><i aria-hidden=\"true\" class=\"fa-toggle icon icon-signet-left-colored\"><\/i><\/div><div id=\"elementor-tab-content-2172\" class=\"eael-accordion-content clearfix\" data-tab=\"2\" aria-labelledby=\"immunosafe-hla2\"><p>Dieses Panel enth\u00e4lt 10 verschiedene Spender, die so zusammengestellt sind, dass sie die h\u00e4ufigsten HLA-Klasse-II-Allele in der kaukasischen Bev\u00f6lkerung abdecken, und enth\u00e4lt oft auch einige der weniger h\u00e4ufigen Allele. ImmunoSafe\u2122-HLA2-Panels sind als Standardprodukte erh\u00e4ltlich und k\u00f6nnen am n\u00e4chsten Tag geliefert werden. Falls das Panel nicht auf Lager ist, betr\u00e4gt die Lieferzeit bis zu 3 Wochen.<\/p><\/div>\n\t\t\t\t\t<\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0d6cb57 elementor-widget elementor-widget-spacer\" data-id=\"0d6cb57\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3fc94cb elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"3fc94cb\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8a2331b\" data-id=\"8a2331b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a2dcaa2 elementor-widget elementor-widget-spacer\" data-id=\"a2dcaa2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-caa717c elementor-widget elementor-widget-heading\" data-id=\"caa717c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Um die Lieferzeit f\u00fcr spezifische Panelzusammensetzungen zu erfragen, kontaktieren Sie uns bitte.<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-adc5878 elementor-widget elementor-widget-spacer\" data-id=\"adc5878\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2599d5e elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"2599d5e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e4dd057\" data-id=\"e4dd057\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d81d543 elementor-widget elementor-widget-spacer\" data-id=\"d81d543\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-4419333 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4419333\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-a96ad39\" data-id=\"a96ad39\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3a092e6 elementor-align-center elementor-invisible elementor-widget elementor-widget-button\" data-id=\"3a092e6\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;pulse&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"mailto:sales@biomex.de\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Kontaktieren Sie unser Vertriebsteam! <\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-7c67a32\" data-id=\"7c67a32\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-06e0415 elementor-align-center elementor-widget__width-auto animated-slow elementor-invisible elementor-widget elementor-widget-button\" data-id=\"06e0415\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;pulse&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/sampleshop.biomex.de\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Besuchen Sie unseren SampleShop<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-0eb3559 elementor-widget__width-auto elementor-hidden-mobile elementor-widget elementor-widget-spacer\" data-id=\"0eb3559\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c367e3c elementor-widget elementor-widget-spacer\" data-id=\"c367e3c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0a79839 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0a79839\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-24600e5\" data-id=\"24600e5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5f4060e elementor-widget elementor-widget-spacer\" data-id=\"5f4060e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-bb9e631 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bb9e631\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-99720b3\" data-id=\"99720b3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-47fa8a7 elementor-widget elementor-widget-heading\" data-id=\"47fa8a7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Gepaarte Plasma- und Serumproben<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3a554e3\" data-id=\"3a554e3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-e1762eb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e1762eb\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-d1d924f\" data-id=\"d1d924f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-90e6611 elementor-widget elementor-widget-text-editor\" data-id=\"90e6611\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Gepaarte Plasma- und Serumproben sind auf Anfrage von Spendern verf\u00fcgbar, die in ImmunoSafe\u2122-Panels aufgenommen wurden, in 1-ml-Aliquots.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-a35510e\" data-id=\"a35510e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-3d8d719 elementor-align-center elementor-invisible elementor-widget elementor-widget-button\" data-id=\"3d8d719\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;pulse&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"mailto:sales@biomex.de\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Kontaktieren Sie unser Vertriebsteam!<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-488552a elementor-widget elementor-widget-spacer\" data-id=\"488552a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-05bc2c0 elementor-widget elementor-widget-menu-anchor\" data-id=\"05bc2c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"services\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cf5f1b4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cf5f1b4\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-872196d\" data-id=\"872196d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0d6ebc8 elementor-widget elementor-widget-spacer\" data-id=\"0d6ebc8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-cce7d71 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cce7d71\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-dd2a77d\" data-id=\"dd2a77d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5c7cf5a elementor-widget elementor-widget-heading\" data-id=\"5c7cf5a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Immunogenit\u00e4ts- und Immunotoxizit\u00e4ts-Dienstleistungen<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-2220e94\" data-id=\"2220e94\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-6d2df33 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6d2df33\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-ceaa741\" data-id=\"ceaa741\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-34419ec elementor-widget elementor-widget-text-editor\" data-id=\"34419ec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Unsere Dienstleistungen im Bereich Immunogenit\u00e4t und Immunotoxizit\u00e4t sind darauf ausgelegt, Ihnen umfassende Informationen zum Risikoprofil Ihres therapeutischen Kandidaten bereitzustellen. Sie erm\u00f6glichen es Ihnen, Ihr Biotherapeutikum weiter zu verfeinern, zu humanisieren oder zu optimieren sowie dessen Potenz und Wirksamkeit zu bewerten.<\/p><p><strong>Unsere Strategie<\/strong><br \/>Wir setzen auf in silico- und in vitro-Assays, um immunogene Epitope zu identifizieren, die Interaktion von Immunzellen zu untersuchen und geeignete Kandidaten auszuw\u00e4hlen.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-cdb957c\" data-id=\"cdb957c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-43e9145 elementor-widget elementor-widget-spacer\" data-id=\"43e9145\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-d6c0ad7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d6c0ad7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-a3433e3\" data-id=\"a3433e3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-83b8b1e elementor-widget elementor-widget-heading\" data-id=\"83b8b1e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Von BIOMEX entwickelte in vitro-Assays umfassen:<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3c30f5f elementor-widget elementor-widget-eael-feature-list\" data-id=\"3c30f5f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-feature-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"-icon-position-left -tablet-icon-position-left -mobile-icon-position-left\">\n\t\t\t<ul id=\"eael-feature-list-3c30f5f\" class=\"eael-feature-list-items circle stacked  eael-feature-list-vertical\" data-layout-tablet=\"vertical\" data-layout-mobile=\"vertical\">\n\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-9b80388\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-0\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">T-Zell-Aktivierung und -Proliferation<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-7114bc6\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-1\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">Aktivierung und Proliferation angeborener Immunzellen<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-14b8d97\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-2\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">DC:T-Zell-Stimulations-Assays<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-6c186e1\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-3\">\n\n\t\t<i aria-hidden=\"true\" class=\"icon icon-signet-left-colored\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">Cytokinsturm-Assay<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\"><\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<\/ul>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0ee6036 elementor-widget elementor-widget-text-editor\" data-id=\"0ee6036\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Wenn Sie an der Entwicklung neuer Assays oder der Untersuchung spezifischer Wirkmechanismen interessiert sind, wird unser Serviceteam eng mit Ihnen zusammenarbeiten, um die optimale L\u00f6sung zu entwickeln.<\/p><p><strong>F\u00fcr weitere Informationen zur Risikominimierung in der Entwicklung Ihres Therapeutikums:<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-1ae1411 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1ae1411\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div 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class=\"elementor-button-text\">Kontaktieren Sie unser Vertriebsteam!<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-1b65e99 elementor-widget elementor-widget-spacer\" data-id=\"1b65e99\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Immunogenit\u00e4t und Immunotoxizit\u00e4t Immunogenit\u00e4t und Immunotoxizit\u00e4t stellen potenzielle Herausforderungen bei der Entwicklung neuer Biotherapeutika, Impfstoffe sowie Zell- und Gentherapien dar. Diese Themen stehen daher im Fokus intensiver Studien und Diskussionen seitens der Regulierungsbeh\u00f6rden und der wissenschaftlichen Gemeinschaft. Unter Immunogenit\u00e4t versteht man die F\u00e4higkeit einer Substanz, eine Immunantwort auszul\u00f6sen. Immunotoxizit\u00e4t hingegen bezeichnet die F\u00e4higkeit einer Substanz, <a class=\"read-more\" href=\"https:\/\/biomex.de\/de\/life-sciences\/anwendungsbereiche\/immunogenitaet-und-immunotoxizitaet\/\">Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":19850,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-19786","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Immunogenit\u00e4t und Immunotoxizit\u00e4t - BIOMEX<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biomex.de\/de\/life-sciences\/anwendungsbereiche\/immunogenitaet-und-immunotoxizitaet\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Immunogenit\u00e4t und Immunotoxizit\u00e4t - BIOMEX\" \/>\n<meta property=\"og:description\" content=\"Immunogenit\u00e4t und Immunotoxizit\u00e4t Immunogenit\u00e4t und Immunotoxizit\u00e4t stellen potenzielle Herausforderungen bei der Entwicklung neuer Biotherapeutika, Impfstoffe sowie Zell- und Gentherapien dar. Diese Themen stehen daher im Fokus intensiver Studien und Diskussionen seitens der Regulierungsbeh\u00f6rden und der wissenschaftlichen Gemeinschaft. Unter Immunogenit\u00e4t versteht man die F\u00e4higkeit einer Substanz, eine Immunantwort auszul\u00f6sen. 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